Fig. 2.

Biopsy taken from a chest wall mass of a 60 year old woman with anthracycline and taxane pre treated breast cancer. The biopsy was taken 93 days after the first dose of Reolysin, (48 h after the third dose). Panel 2a: Pharmacodynamic Effect: Hematoxylin and Eosin stain of the biopsy showing extensive necrosis (also seen in 2b) of the tumor suggestive of anti-tumor activity. Panel 2b: Virokinetics: Electron Microscopy of the same biopsy specimen showing viral replication and remnant capsids/ghosts, typical of findings after prolonged interval between viral exposure and tissue collection, and with evidence of tissue necrosis