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. Author manuscript; available in PMC: 2013 Dec 4.
Published in final edited form as: Invest New Drugs. 2009 Jul 2;28(5):10.1007/s10637-009-9279-8. doi: 10.1007/s10637-009-9279-8

Table 3.

Toxicities across all patients across all doses

Dose Level 1
2
3
4
5
6
TCID50 1×108
3×108
1×109
3×109
1×1010
3×1010
G1 G2 G1 G2 G1 G2 G1 G2 G1 G2 G1 G2
Fever 2 1 3
Chills 1 1 1 1
Myalgia 1 2 3 2
Headache 2 1 1 1
Sore throat/Nasal fullness 2 1 2
Fatigue 2 1 1 2 1
Dehydration 1
Nausea 1 1 1 2
Vomiting 1 1 1
Diarrhea 1 3 1
Constipation 1 1
Bloating 1
Anorexia 1 1 1 1
Dysgeusia 1
Skin rash 1

Abbreviations: TCID50 tissue culture infective dose, G1 grade 1, G2 grade 2