Table IV.
Total THC concentrations observed in rabbit ocular tissues 1 h post topical administration of 50 μL of THC in light mineral oil (0.1% w/v), emulsion (0.37% w/v) or micellar solutions (0.125 % w/v THC, 0.5% Cremophor RH 40 + 0.1% EDTA + 0.02% BAK + 0.5% HPMC). Results are depicted as mean ± SD (n=3).
| Tissue | THC
|
|||
|---|---|---|---|---|
| Light mineral oil | Emulsion | 0.5% Cremophor RH 40 + 0.1% EDTA + 0.02% BAK + 0.5% HPMC | ||
| Drug concentration in terms of THC (% w/v) | 0.1 | 0.37 | 0.125 | |
|
| ||||
| pH | NT** | 7.4 | 7.4 | |
|
| ||||
| Osmolality | NT** | NT** | 290 | |
|
| ||||
| Cornea (ng/50 mg Tissue) | 68.8 ± 14.5 | 300.6 ± 79.6 | 553.9 ± 87.4 | |
|
| ||||
| Aqueous Humor (ng/100 μL) | ND* | ND* | ND* | |
|
| ||||
| Iris-Cilliary Body (ng/50 mg Tissue) | ND* | ND* | ND* | |
|
| ||||
| Vitreous Humor (ng/mL) | ND* | ND* | ND* | |
|
| ||||
| Retina-Choroid (ng/50 mg Tissue) | ND* | ND* | ND* | |
|
| ||||
| Sclera (ng/250 mg Tissue) | 104.1 ± 36.1 | 171.1 ± 66.6 | 439.3 ± 280.2 | |
*
ND - Drug concentration below detection limit
**
NT - Not Tested