. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: Pharm Res. 2013 Jun 5;30(8):10.1007/s11095-013-1072-x. doi: 10.1007/s11095-013-1072-x

Table V.

Total THC concentrations observed in rabbit ocular tissues post topical administration of 50 μL of THC-HG formulated in, 0.5% Cremophor RH 40 + 0.1% EDTA + 0.02% BAK + 0.5% HPMC (1 h time point) or ion pair formulation (8 mM tromethamine + 0.5% HPMC; 1 and 3 h time points). Results are depicted as mean ± SD (n=3).

Tissue	THC-HG
	0.5% Cremophor RH 40 + 0.1% EDTA+0.02% BAK + 0.5% HPMC	Ion Pair Formulation
	1 Hour	1 Hour	3 Hours
	Drug Concentration in terms of THC (% w/v)	0.18	0.16	0.16
pH	7.4	7.6
Osmolality (mOsm)	289	286
Cornea (ng/50 mg Tissue)	2451.6 ± 645.6	2245.7 ± 240.2	1382.7 ± 109.8
Aqueous Humor (ng/100 μL)	32.1 ± 12.6	52.2 ± 18.7	27.3 ± 11.3
Iris-Cilliary Body (ng/50 mg Tissue)	35.6 ± 12.5	93.1 ± 41.4	67.1 ± 55.6
Vitreous Humor (ng/mL)	ND^*	ND^*	ND^*
Retina-Choroid (ng/50 mg Tissue)	ND^*	ND^*	ND^*
Sclera (ng/250 mg Tissue)	354.7 ± 86.4	2258.1 ± 1331.1	166.1 ± 49.4

ND - Drug concentration below detection limit