Figure 7.

Interindividual different and delayed response to dabigatran etexilate (Group 5). Sheep were treated with 600 mg dabigatran etexilate for 7 days. A: Dabigatran could be detected in plasma 4–8 hours after the first oral application of 600 mg dabigatran. Highly individual differences between sheep were noticed. B: Both on days 4 and 7, maximum dabigatran concentrations were measured at a time point of 6 hours. Twenty-four hours after the last administration, dabigatran plasma concentration was 0.034 ± 0.027 μg/mL. There were no significant differences when comparing reference values (0.000 μg/mL) and maximum dabigatran plasma levels on days 1, 4 and 7 (one-way repeated measures ANOVA, post hoc Bonferroni Test). C: Interindividual differences could be noted when considering values of the single sheep at the different measurement time points. Only 2 sheep reached plasma concentrations of dabigatran in the range of human values on day 7.