Table 4.

Invasive lung function measurements after desimaprimine, zoledronic acid and sphingolactone treatment

Parameter	Unit	Control (n=9)	Elastase (n=10)	Elastase + desimaprimine (n=5)	Elastase + zoledronic acid (n=4)	Elastase + sphingolactone (n=4)
Resistance (R)	cmH2O/mL	0.67 ± 0.07	0.52 ± 0.03*	0.47 ± 0.02 *	0.49 ± 0.01*	0.54 ± 0.05*
Compliance (C)	mL/cmH2O	0.032 ± 0.004	0.052 ± 0.004*	0.066 ± 0.007*	0.067 ± 0.011*	0.054 ± 0.007*
Airway Resistance (Rn)	cmH2O/mL	0.32 ± 0.03	0.23 ± 0.03*	0.22 ± 0.02*	0.25 ± 0.01*	0.21 ± 0.02*
Tissue Elasticity (H)	cmH2O/mL	32.4 ± 4.2	16.9 ± 2.3*	13.2 ± 1.3*	13.9 ± 2.8*	15.5 ± 2.7*
Total lung capacity (A)	mL	0.70 ± 0.05	0.78 ± 0.04	0.88 ± 0.02	0.89 ± 0.07	0.77 ± 0.03
Inspiratory Capacity (B) from zero pressure	mL	1.14 ± 0.09	1.30 ± 0.11*	1.47 ± 0.028*	1.57 ± 0.19*	1.29 ± 0.09*
Static Compliance (Cst)	mL/cmH2O	0.078 ± 0.008	0.094 ± 0.009*	0.108 ± 0.002*	0.115 ± 0.014*	0.094 ± 0.008*

During invasive lung function measurements, an average for each individual mouse was calculated from 4 accepted (coefficient of determination: COD>0.95) measurements for each parameter. * p<0.05 when compared to Control.