Table 5.
IC50(μg/ml) values of crude and fractionated extracts of Alpinia pahangensis against selected cell lines
|
Extract/ fraction |
Inhibition concentration, IC50(μg/ml) |
||||||
|---|---|---|---|---|---|---|---|
| KB | MCF7 | A549 | Ca Ski | HCT 116 | HT-29 | MRC-5 | |
|
Methanol |
>100 |
>100 |
>100 |
>100 |
>100 |
>100 |
>100 |
|
Hexane |
5.8 ± 0.1 |
22.0 ± 1.3 |
16.6 ± 0.2 |
18.4 ±0.2 |
9.1 ± 2.0 |
16.9 ± 0.5 |
17.3 ± 0.5 |
|
Ethyl acetate |
10.2 ± 0.3 |
50.3 ± 0.3 |
25.9 ± 1.4 |
35.3 ± 2.0 |
19.9 ± 1.1 |
38.4 ± 0.4 |
44.0 ± 3.0 |
|
Water |
>100 |
>100 |
>100 |
>100 |
>100 |
>100 |
>100 |
| Doxorubicin | 0.46 ± 0.02 | 0.088 ± 0.01 | 1.01 ± 0.02 | 0.31 ± 0.10 | 0.41 ± 0.07 | 0.56 ± 0.05 | 0.69 ± 0.05 |
Each value is expressed as mean ± standand deviation of triplicate measurements.
Data are expressed as IC50 in μg/ml which is the concentration of extract requires to inhibit cell growth by 50%).