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. 2013 Jun 7;5(5):723–735. doi: 10.4161/mabs.25282

graphic file with name mabs-5-723-g5.jpg

Figure 5. SMIP-016GV mediates enhanced ADCC in cells expressing a range of surface CD37. (A) Quantification of surface CD37 on parental 697 (697), 697-CD37 clones V1, V2 and V3 by flow cytometry. (B) ADCC assay with normal donor NK cell effectors against the different 697 cell clones as targets at a 25:1 E:T ratio. SMIP-016 and SMIP-016GV were used in decreasing concentrations (n = 4 NK donors). Increasing surface CD37 levels enhanced ADCC with both the SMIP-016GV (p = 0.002) and SMIP-016 (p = 0.0005).

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