Figure 6. SMIP-016^GV mediates effective NK cell ADCC against primary Acute Lymphoblastic Leukemia cell. (A) Quantification of surface CD37 by flow cytometry shows ALL cells (n = 9) have significantly lower levels of surface CD37 than CLL B cells (n = 20) (p = 0.0051) and normal B cells (n = 5) (p < 0.0001). (B) SMIP-016 and SMIP-016^GV show comparable levels of modest direct cytotoxicity against primary ALL bone marrow samples (n = 4) (p = 0.74) (C) ADCC using ALL bone marrow samples as targets and normal donor NK cell effectors shows enhanced ADCC with SMIP-016^GV compared with SMIP-016. (n = 8 ALL samples × 3 NK cell effectors each) (p < 0.0036 for all E:T ratios tested.