Table 4. Peak Serum levels (Cmax) and half-life (t ½) of ch14.18/CHO in patients.
| ch14.18/ CHO: Cmax (1st courses only) * | ch14.18/ SP2/0(11): Cmax * | ||||||
|---|---|---|---|---|---|---|---|
| Dose level (mg/m2/d) |
Range (µg/ml) |
Mean § (µg/ml) |
n |
Dose level (mg/m2/d) |
Range (µg/ml) |
Mean § (µg/ml) |
n |
| 10 |
9.5 – 10.7 |
9.9 ± 0.6 |
3 |
10 |
2.4–15.6 |
9.5 ± 6.0 |
5 |
| 20 |
7.4 – 26.6 |
16.5 ± 5.9 |
8 |
20 |
12.3–23.7 |
19.3 ± 6.0 |
3 |
| 30 |
17.0 – 27.4 |
22.4 ± 5.1 |
3 |
50 |
16.6–57.0 |
34.8 ± 20.5 |
3 |
| |
|
||||||
| ch14.18/ CHO: t½ † |
ch14.18/ SP2/011: t½ † |
||||||
| Dose level (mg/m2/d) |
Range (h) |
Mean § (h) |
n |
Dose level (mg/m2/d) |
Range (h) |
Mean § (h) |
n |
| 10–30 |
25.6 - 196.6 |
76.9 ± 52.5 |
12 |
10–50 |
29.1 - 110.8 |
66.6 ± 27.4 |
9 |
| |
|
||||||
| 1st course ch14.18/ CHO: t½ |
2nd course ch14.18/ CHO: t½ |
||||||
| Dose level (mg/m2/d) |
Range (h) |
Mean § (h) |
n |
Dose level (mg/m2/d) |
Range (h) |
Mean § (h) |
n |
| 20 |
25.6 - 196.6 |
99.7 ± 58.8 |
7 |
20 |
23 - 203.6 |
92.1 ± 77.0 |
5 |
| 30 | 30.2 - 66.2 | 43.1 ± 20.0 | 3 | 30 | 18.7 - 27.8 | 22.7 ± 4.6 | 3 |
Legend: * Cmax (µg/ml) and † t½ (h) in patients treated with ch14.18/CHO are compared with results reported for ch14.18/SP2/0.(11) § Data represent mean values ± standard deviation.