Table 4.
Time to index DMT discontinuation: cox proportional hazard models for experienced and naïve DMT users
| Experienced DMT Users | Naïve DMT Users | |||
|---|---|---|---|---|
| |
Hazard ratio |
95% Confidence interval |
Hazard ratio |
95% Confidence interval |
| DMT initiated |
|
|
|
|
| Fingolimod |
Reference |
|
Reference |
|
| Interferon beta-1b |
2.83 |
(1.62-4.93) |
1.90 |
(1.25-2.89) |
| Intramuscular interferon beta-1a |
2.43 |
(1.49-3.97) |
1.53 |
(1.03-2.28) |
| Subcutaneous interferon beta-1a |
2.42 |
(1.54-3.82) |
1.58 |
(1.05-2.38) |
| Glatiramer acetate |
1.73 |
(1.11-2.69) |
1.53 |
(1.04-2.24) |
| Gender |
|
|
|
|
| Male |
Reference |
|
Reference |
|
| Female |
1.45 |
(0.99-2.11) |
1.07 |
(0.89-1.29) |
| Age categories |
|
|
|
|
| 18-44 |
Reference |
|
Reference |
|
| 45-54 |
0.78 |
(0.55-1.11) |
0.81 |
(0.68-0.98) |
| 55-64 |
0.97 |
(0.65-1.46) |
0.75 |
(0.60-0.94) |
| 65+ |
0.80 |
(0.38-1.69) |
0.67 |
(0.44-1.01) |
| Region |
|
|
|
|
| West |
Reference |
|
Reference |
|
| Northeast |
0.68 |
(0.40-1.15) |
0.78 |
(0.60-1.01) |
| Midwest |
0.99 |
(0.62-1.59) |
0.88 |
(0.69-1.13) |
| South |
1.19 |
(0.75 -1.87) |
0.88 |
(0.69-1.12) |
| Prior authorization for index prescription |
1.21 |
(0.88-1.65) |
1.25 |
(1.06-1.48) |
| Copayment for index prescription |
|
|
|
|
| 0-<30 |
Reference |
|
Reference |
|
| 30-100 |
0.93 |
(0.65-1.32) |
0.95 |
(0.78-1.15) |
| 100+ |
0.92 |
(0.59-1.45) |
0.88 |
(0.70-1.09) |
| Mail order for index prescription |
1.10 |
(0.59-2.07) |
0.57 |
(0.42-0.78) |
| Pharmacy type for index prescription |
|
|
|
|
| Retail |
Reference |
|
Reference |
|
| Accredo |
1.03 |
(0.54 -1.97) |
1.05 |
(0.77-1.43) |
| Other specialty pharmacy | 1.69 | (0.86-3.31) | 0.78 | (0.56-1.07) |
Bold numbers indicate that the hazard ratios are significantly different from 1 at p<0.05.