Table 1.
Microarray vs. RNA-seq
Microarray | RNA-seq | |
---|---|---|
Principle | Hybridization | Cloning & sequencing |
Required amount of RNA | High | Low |
Resolution | Several to 100 bp | Single base |
Distinguish Allelic expression? | Limited | Yes |
Distinguish splice forms? | Limited | Yes |
Discover new genes? | No | Yes |
Strandedness? | No | Yes |
Dynamic range | Few hundred-fold | > 8000-fold |
Reproducibility | Yes | Yes |
Cost | Medium | High (due to computation) |