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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Neurochem. 2013 Jul 19;127(4):10.1111/jnc.12360. doi: 10.1111/jnc.12360

Figure 2.

Figure 2

Treatment with the GHRH agonist JI-34 prevents IH-induced adverse effects on retention of a hippocampal spatial task in the water maze and the deleterious effects of IH on forced swim test in mice. Administration of the GHRH antagonist MIA-602 adversely affects spatial task retention and forced swim performance in normoxic mice but is not additively deleterious to IH. Mean percentage time in the target quadrant during probe trials after completion of water maze testing in mice treated with either J1-34 (A) and Mice exposed to intermittent hypoxia and treatment with J1-34 (B) Data are mean ± SEM. (*IH-VEH vs. RA-VEH, p <0.05; One-way ANOVA).

Mean percentage time in the target quadrant during probe trials after completion of water maze testing in mice treated MIA-602 (C) during intermittent hypoxia and mice exposed to intermittent hypoxia and treatment with MIA 602 (D) during the forced swim test. Data are mean ± SEM. (*IH-VEH and IH-MIA 602 vs. RA-VEH, p <0.05; One-way ANOVA).