Table 1.
Study group compositions and daily dosing scheme for borage and echium seed oils in the four groups of subjects
| Group 1 | Group 2 | Group 3 | Group 4 | |
|---|---|---|---|---|
|
No. of Subjects |
6 |
9 |
11 |
11 |
| (female) |
(3) |
(5) |
(6) |
(7) |
|
Age (range) |
22–46 |
18–54 |
19–58 |
22–64 |
|
No. of subjects withdrawn |
1 |
1 |
1 |
2 |
|
Echium Oil Dose (g) |
14 |
7 |
4 |
2 |
| No. of daily capsules |
14 |
7 |
4 |
2 |
| ALA (g) |
4.02 |
2.01 |
1.15 |
0.57 |
| SDA (g) |
1.75 |
0.875 |
0.5 |
0.25 |
| GLA (g) |
1.54 |
0.77 |
0.44 |
0.22 |
|
Borage Oil Dose (g) |
0 |
3.9 |
5.2 |
5.2 |
| No. of daily capsules |
0 |
3 |
4 |
4 |
| ALA (g) |
<0.01 |
<0.01 |
<0.01 |
<0.01 |
| SDA (g) |
0 |
0 |
0 |
0 |
| GLA (g) |
0 |
0.9 |
1.2 |
1.2 |
|
Total |
|
|
|
|
| No. of daily capsules |
14 |
10 |
8 |
6 |
| ALA (g) |
4.02 |
2.01 |
1.15 |
0.57 |
| SDA (g) |
1.75 |
0.875 |
0.5 |
0.25 |
| GLA (g) | 1.54 | 1.67 | 1.64 | 1.44 |
The number of daily capsules, containing 1 g (EO) or 1.3 g (BO) oil per capsule, and the amount of ALA, SDA and GLA provided by the encapsulated echium and borage oils is shown for each dosing group. Recruitment into Group 1 was stopped after the interim analyses showed that the highest dose of EO was not required to prevent elevations of AA levels in circulating plasma.