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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Cancer Res. 2013 Oct 11;73(23):10.1158/0008-5472.CAN-13-1075. doi: 10.1158/0008-5472.CAN-13-1075

Figure 5. CO arrests growth of established prostate and lung cancer.

Figure 5

A–B. Immunohistochemistry analysis with antibody against Ki67 and histological analysis (H&E) was performed on the tissues from wild type (wt) or TRAMP mice that were treated with CO (250 ppm/daily/5 days per week) or untreated (Air). Quantitation of Ki67 staining is shown in A (n=6–7 mice per group). C. Immunohistochemistry with antibodies to HO-1 was applied in the normal (wt) and PIN lesion containing prostates (TRAMP) as well as in the lung tumors of FVB/N-Tg(teto-Kras2)12Hev (provided by Dr. Varmus). Scale bar, 200 µm. D. Immunostaining of prostates from TRAMP treated as above with antibodies to mitochondrial transcription factor A. Two representative pictures from Air and CO treated mice are shown. Scale bar, 200 µm. E–F. H&E staining in the lungs of FVB/N-Tg(teto-Kras2)12Hev mice that were treated with doxycycline for 8 weeks and continued with CO treatment for the following 5 weeks. The number of nodules in the lung cross-sections was evaluated in at least n=5–6 per animal. The representative sections and immunohistochemistry with antibody against Ki-67 are shown in F. Data are representative for Air n=8, CO n=9 animals. P<0.0002. Scale bar, 200 µm.