Table 4.

Affected RPE-choroidal signaling pathways at different locations of cladogram in Figure 2. Sample identification follows http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29801. Updates on genes' functions can be obtained from http://www.ncbi.nlm.nih.gov/gene/.

Dry 135 (Sample GSM738566) Lower part of the cladogram	Dry 145 (Sample GSM738575) Middle part of the cladogram	Dry 136 (Sample GSM738567) Upper part of the cladogram
(1) CXCL12: activates lymphocytes (2) GDNF: promotes the survival and differentiation of dopaminergic neurons (3) MAPK1: proliferation, differentiation, transcription regulation, and development (4) PIK3CA: oncogenic (5) SFRP1: soluble modulator of Wnt signaling (6) SOD1 superoxide dismutase 1	(1) ABL1 protooncogene implicated in cell differentiation, division, adhesion, and stress response (2) CAV1: cell cycle (3) CCL20: inflammation (4) CREB1: a transcription factor, cAMP pathway (5) CRY2: insulin metabolism (6) ERCC1: DNA repair (7) ESR1: hormone binding, DNA binding, and activation of transcription (8) IL8: inflammatory response (9) INS: insulin (10) MSN: cytoskeleton (11) MT1A: cytoskeleton, and so forth (12) PML: tumor suppressor (13) SERPINE1: inhibitor of fibrinolysis (14) TBP: assembly of transcription complex, and acts as a channel for regulatory signals (15) TMSB4X: cytoskeleton, proliferation, migration, and differentiation	(1) CAV1: cell cycle (2) CCL5: inflammation (3) CXCL12: activates lymphocytes (4) EGF: growth, proliferation, and differentiation (5) PPARA peroxisome proliferator-activated receptor alpha