Table 3.
Radioactivity associated to setipiprant and each of its metabolites expressed as percentage of the administered dose excreted in feces
| Metabolite ID | RTRD (min) | % of administered dose excreted in feces | ||||
|---|---|---|---|---|---|---|
| 0–24 h | 24–48 h | 48–72 h | 72–96 h | 96–120 h | ||
| Unknown | 2.6 | 0.65 | ND | ND | ND | ND |
| L | 17.5 | ND | ND | ND | ND | ND |
| M (m/z 540) | 20.3 | ND | ND | ND | ND | ND |
| E (m/z 540) | 22.1 | ND | ND | ND | ND | ND |
| P | 23.9 | ND | ND | ND | ND | ND |
| M9 (m/z 437) | 26.2 | 0.78 | 2.92 | 2.76 | 1.30 | 0.48 |
| M7 (m/z 437) | 27.8 | 1.70 | 5.25 | 5.22 | 2.24 | 0.85 |
| Q | 29.9 | ND | ND | ND | ND | ND |
| R | 33.1 | ND | ND | ND | ND | ND |
| C (m/z 579) | 34.0 | ND | ND | ND | ND | ND |
| W1 (m/z 419) | 34.6 | 0.09 | 0.26 | 0.27 | 0.15 | 0.10 |
| W2 (m/z 419) | 35.0 | |||||
| W3 (m/z 419) | 35.5 | 0.08 | 0.16 | 0.22 | 0.10 | BLQ |
| I (m/z 579) | 35.2 | ND | ND | ND | ND | ND |
| J (m/z 579) | 35.9 | ND | ND | ND | ND | ND |
| T (m/z 449) | 36.1 | 0.10 | 0.54 | 0.40 | 0.19 | 0.14 |
| V (m/z 419) | 36.5 | 0.10 | 0.29 | 0.31 | 0.14 | BLQ |
| D (m/z 579) | 36.7 | ND | ND | ND | ND | ND |
| U (m/z 449; m/z 419) | 37.0 | 0.08 | 0.27 | 0.23 | 0.09 | BLQ |
| X | 37.4 | 0.05 | ND | ND | ND | ND |
| Z (m/z 579) | 37.7 | ND | ND | ND | ND | ND |
| K (m/z 449; m/z 419) | 38.3 | 0.11 | 0.43 | 0.34 | 0.16 | BLQ |
| Y | 40.3 | ND | 0.08 | ND | ND | ND |
| Setipiprant (m/z 403) | 42.4 | 13.73 | 17.57 | 9.98 | 7.04 | 1.72 |
| G | 58.3 | BLQ | 0.13 | 0.09 | BLQ | ND |
| H | 59.5 | 0.16 | 0.22 | 0.16 | 0.12 | ND |
BLQ below limit of quantification, ND not detected, RD radio detection, RT retention time