Table 4.
Radioactivity associated to setipiprant and each of its metabolites excreted in urine expressed as percentage of the administered dose for the respective urine collection intervals
| Metabolite ID | RTRD (min) | % of administered dose excreted in urine | ||||
|---|---|---|---|---|---|---|
| 0–8 h | 8–16 h | 16–24 h | 24–48 h | 48–72 h | ||
| Unknown | 2.6 | 0.10 | ND | ND | ND | ND |
| L | 17.5 | 0.09 | ND | ND | ND | ND |
| M (m/z 540) | 20.3 | 0.06 | 0.02 | BLQ | ND | ND |
| E (m/z 540) | 21.2 | 0.12 | 0.03 | BLQ | ND | ND |
| P | 23.9 | 0.10 | BLQ | ND | ND | ND |
| M9 (m/z 437) | 26.2 | 0.84 | 0.14 | 0.06 | BLQ | ND |
| M7 (m/z 437) | 27.8 | 3.29 | 0.81 | 0.26 | 0.33 | 0.09 |
| Q | 29.9 | 0.05 | ND | ND | ND | ND |
| R | 33.1 | 0.23 | 0.04 | BLQ | ND | ND |
| C (m/z 579) | 34.0 | 0.08 | BLQ | ND | ND | ND |
| W1 (m/z 419) | 34.6 | 0.05 | ND | ND | ND | ND |
| W2 (m/z 419) | 35.0 | |||||
| W3 (m/z 419) | 35.5 | BLQ | ND | ND | ND | ND |
| I (m/z 579) | 35.2 | |||||
| J (m/z 579) | 35.9 | 0.03 | ND | ND | ND | ND |
| T (m/z 449) | 36.1 | |||||
| V (m/z 419) | 36.5 | 0.32 | 0.07 | BLQ | ND | ND |
| D (m/z 579) | 36.7 | |||||
| U (m/z 449; m/z 419) | 37.0 | ND | ND | ND | ND | ND |
| X | 37.4 | ND | ND | ND | ND | ND |
| Z (m/z 579) | 37.7 | 0.05 | BLQ | ND | ND | ND |
| K (m/z 449; m/z 419) | 38.3 | |||||
| Y | 40.3 | ND | ND | ND | ND | ND |
| Setipiprant (m/z 403) | 42.4 | 3.13 | 0.37 | 0.11 | 0.12 | BLQ |
| G | 58.3 | ND | ND | ND | ND | ND |
| H | 59.5 | ND | ND | ND | ND | ND |
BLQ below limit of quantification, ND not detected, RD radio detection, RT retention time