Table 5.
Overall metabolic profile of setipiprant in the excreta of the study subjects
| Metabolite ID | RTRD (min) | % of Aadministered excreted | % of Aadministered excreted | |
|---|---|---|---|---|
| Urine | Feces | Urine and feces | ||
| Unknown | 2.6 | 0.10 | 0.65 | 0.75 |
| L | 17.5 | 0.09 | ND | 0.09 |
| M (m/z 540) | 20.3 | 0.08 | ND | 0.08 |
| E (m/z 540) | 21.2 | 0.15 | ND | 0.15 |
| P | 23.9 | 0.10 | ND | 0.10 |
| M9 (m/z 437) | 26.2 | 1.04 | 8.24 | 9.28 |
| M7 (m/z 437) | 27.8 | 4.78 | 15.26 | 20.04 |
| Q | 29.9 | 0.05 | ND | 0.05 |
| R | 33.1 | 0.27 | ND | 0.27 |
| C (m/z 579) | 34.0 | 0.08 | ND | 0.08 |
| W1 (m/z 419) | 34.6 | 0.05 | 0.87 | 0.92 |
| W2 (m/z 419) | 35.0 | |||
| W3 (m/z 419) | 35.5 | BLQ | 0.56 | 0.56 |
| I (m/z 579) | 35.2 | ND | BLQ | |
| J (m/z 579) | 35.9 | 0.03 | 1.37 | 1.40 |
| T (m/z 449) | 36.1 | |||
| V (m/z 419) | 36.5 | 0.39 | 0.84 | 1.23 |
| D (m/z 579) | 36.7 | |||
| U (m/z 449; m/z 419) | 37.0 | ND | 0.67 | 0.67 |
| X | 37.4 | ND | 0.05 | 0.05 |
| Z (m/z 579) | 37.7 | 0.05 | 1.04 | 1.09 |
| K (m/z 449; m/z 419) | 38.3 | |||
| Y | 40.3 | ND | 0.08 | 0.08 |
| Setipiprant (m/z 403) | 42.4 | 3.73 | 50.04 | 53.77 |
| G | 58.3 | ND | 0.22 | 0.22 |
| H | 59.5 | ND | 0.66 | 0.66 |
BLQ below limit of quantification, ND not detected, % of A administered % of administered radioactive dose, RD radio detection, RT retention time