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. 2013 Oct 3;6:76. doi: 10.1186/1756-8722-6-76

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Copyright © 2013 Kim et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prognoses according to specific chromosomal abnormalities. (A) Forest plots showing hazard ratios obtained by univariate Cox analysis for overall survival (OS) and progression-free survival (PFS) according to the presence of specific chromosomal abnormalities using patients with lymphoma bone marrow involvement and normal karyotype as a reference group in 327 patients having either abnormal karyotypes or histologic BM involvement. (B) Based on a cluster analysis of 33 frequent numerical abnormalities and breakpoints, 138 patients with ≥ 2 chromosomal abnormalities were segregated into clusters with characteristic abnormality patterns. The horizontal labels indicate clusters (red, Cluster 1; yellow, Cluster 2; green, Cluster 3; blue, Cluster 4; cyan, Cluster 5; purple, Cluster 6; and black, Cluster 7). The characteristic loci of the abnormalities in each cluster are indicated in red, and the loci associated with a poor prognosis in the univariate analysis are indicated in blue in the right panel. (C) The (OS) and PFS of each cluster is plotted.