Table 2.
Recent studies concerning CPAP and surfactant administration
| Study (ref) | Year | N | Population | Outcome | Groups | ||
|---|---|---|---|---|---|---|---|
|
COIN Trial (78) |
2008 |
610 |
25-28 wks |
|
CPAP |
Systematic intubation |
|
| |
|
|
|
Death or BPD |
33.9% |
38.9% |
|
| |
|
|
|
Intubation |
46% |
100% |
|
| |
|
|
|
Selective surfactant |
38%*** |
77% |
|
| |
|
|
|
Pneumothorax |
9%*** |
3% |
|
|
Rojas et al. (79) |
2009 |
279 |
27-31 wks |
|
CPAP |
Intubation-early surfactant-extubation |
|
| |
|
|
|
Need for MV |
39%* |
26% |
|
| |
|
|
|
Pneumothorax |
9% |
2% |
|
| |
|
|
|
Rescue surfactant |
26%** |
12% |
|
| |
|
|
|
BPD at 36 wks PMA |
59% |
49% |
|
|
CURPAP Trial (80) |
2010 |
208 |
25-28 wks |
|
CPAP Early selective Surfactant |
Prophylactic surfactant |
|
| |
|
|
|
Need for MV |
33% |
31.4% |
|
| |
|
|
|
Death at 36 wks PMA |
10.7% |
8.6% |
|
| |
|
|
|
Pneumothorax |
1% |
6.7% |
|
| |
|
|
|
BPD |
11.7% |
14.3% |
|
|
SUPPORT Trial (81) |
2010 |
1316 |
24-28 wks |
|
CPAP |
Intubation-early surfactant use |
|
| |
|
|
|
Death or BPD |
48.7% |
54.1% |
|
| |
|
|
|
Surfactant use |
67.1%*** |
98.9% |
|
| |
|
|
|
Air leak |
6.8% |
7.4% |
|
|
Dunn et al. (82) |
2011 |
648 |
26-29 wks |
|
CPAP Selective surfactant |
Prophylactic surfactant |
Intubation-early surfactant-extubation |
| |
|
|
|
Surfactant use |
14.8%*** |
98.6% |
98.2% |
| |
|
|
|
Death or BPD |
30.5% |
36.5% |
28.5% |
| Pneumothorax | 5.4% | 4.8% | 3.2% | ||||
BPD=bronchopulmonary dysplasia, PMA=postmenstrual age, MV=mechanical ventilation; wks: weeks of gestation.
*:p<0.05; **:p<0.01; ***:p<0.001.