Table 3.
Emerging approaches to surfactant administration
| Emerging approaches | Advantages | Disadvantages | |
|---|---|---|---|
|
MIST |
Nasopharyngeal instillation |
Painless |
Not well evaluated |
| Loss of surfactant | |||
| Laryngeal mask |
Supraglottic device |
Painful |
|
| Feeding catheter |
Endotracheal administration Under nasal CPAP |
Magill forceps |
|
| Laryngoscopy | |||
| Painful and traumatic? | |||
| Vascular catheter |
Endotracheal administration |
Laryngoscopy |
|
| Under nasal CPAP |
Painful and traumatic |
||
| Easy to use (rigid catheter) |
|
||
| NIST | Aerosolization | Painless | Technically challenging |
MIST: Minimally-Invasive Surfactant Therapy.
NIST: Non-Invasive Surfactant Therapy.