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. 2013 Dec 5;4:271. doi: 10.3389/fgene.2013.00271

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Copyright © 2013 Kikuchi, Tsuji, Yagi, Matsusaka, Tsuji, Kurebayashi, Ogawa, Aburatani and Kaneda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Confirmation of aberrant methylation by pyrosequencing. Six genes were randomly chosen among the 25 frequently methylated genes, and their methylation status was quantitatively validated by pyrosequencing, using the 14 papillary thyroid cancer samples and 10 normal thyroid samples that were analyzed by Infinium. Although one normal sample showed high methylation in POU4F2, aberrant methylation of the six genes in the papillary cancer samples was confirmed. Bottom, the corresponding data for aberrant methylation obtained by Infinium analysis (Figure 3).