Table 2.
CML treatment restrictions, negative medication experiences, and overall disease burden, according to current CML treatment
| |
Imatinib |
Dasatinib |
Nilotinib |
Imatinib vs. Dasatinib |
Imatinib vs. Nilotinib |
Dasatinib vs. Nilotinib |
|||
|---|---|---|---|---|---|---|---|---|---|
| |
(N=208) |
(N=38) |
(N=49) |
|
|
|
|||
| N | % | N | % | N | % | p-value | p-value | p-value | |
| Treatment Restrictions |
|
|
|
|
|
|
|
|
|
|
Dietary Restrictions |
|
|
|
|
|
|
|
|
|
| While fasting |
5 |
2.40% |
0 |
0.00% |
42 |
85.71% |
0.33 |
<.01 |
<.01 |
| With food |
146 |
70.19% |
14 |
36.84% |
2 |
4.08% |
<.01 |
<.01 |
<.01 |
| Without certain foods |
88 |
42.31% |
16 |
42.11% |
36 |
73.47% |
0.98 |
<.01 |
<.01 |
| With water |
131 |
62.98% |
15 |
39.47% |
32 |
65.31% |
<.01 |
0.76 |
0.02 |
| Dissolve tablets in water and drink immediately |
3 |
1.44% |
0 |
0.00% |
1 |
2.04% |
0.46 |
0.76 |
0.38 |
| Without other non-CML medications |
22 |
10.58% |
2 |
5.26% |
9 |
18.37% |
0.31 |
0.13 |
0.07 |
|
Dosing Requirements |
|
|
|
|
|
|
|
|
|
| Once each day |
105 |
50.48% |
17 |
44.74% |
3 |
6.12% |
0.52 |
<.01 |
<.01 |
| Twice each day |
15 |
7.21% |
5 |
13.16% |
32 |
65.31% |
0.22 |
<.01 |
<.01 |
| Two or more pills at one time |
26 |
12.50% |
3 |
7.89% |
24 |
48.98% |
0.42 |
<.01 |
<.01 |
| At specific times of the day |
101 |
48.56% |
19 |
50.00% |
31 |
63.27% |
0.87 |
0.06 |
0.22 |
| At specific hours apart |
32 |
15.38% |
7 |
18.42% |
38 |
77.55% |
0.64 |
<.01 |
<.01 |
| |
Mean |
SD |
Mean |
SD |
Mean |
SD |
p-value |
p-value |
p-value |
| Treatment Restriction Score |
−0.06 |
0.69 |
−0.31 |
0.77 |
0.61 |
0.68 |
0.06 |
<.01 |
<.01 |
| No. Treatment Doses (times per day) |
1.20 |
0.50 |
1.32 |
0.62 |
1.88 |
0.39 |
0.27 |
<.01 |
<.01 |
| Negative Medication Experience |
|
|
|
|
|
|
|
|
|
| Experienced Score |
0.06 |
0.90 |
−0.10 |
0.98 |
0.07 |
0.91 |
0.35 |
0.96 |
0.42 |
| Bothersome Score |
0.02 |
0.70 |
0.10 |
0.62 |
0.07 |
0.74 |
0.47 |
0.66 |
0.83 |
| Impact Score |
0.02 |
0.66 |
0.10 |
0.57 |
0.11 |
0.65 |
0.45 |
0.38 |
0.93 |
| No. Non-CML Medications per day |
2.02 |
2.67 |
2.47 |
4.07 |
2.27 |
2.77 |
0.52 |
0.58 |
0.79 |
| Time since CML diagnosis (years) |
4.85 |
4.31 |
5.32 |
4.47 |
3.69 |
4.14 |
0.55 |
0.09 |
0.09 |
| Time on Current CML Treatment (years) |
4.60 |
2.98 |
2.07 |
1.69 |
1.55 |
1.35 |
<.01 |
<.01 |
0.12 |
| No. Comorbidities | 1.17 | 2.13 | 1.97 | 3.19 | 1.59 | 2.71 | 0.14 | 0.32 | 0.56 |
Note: CML=Chronic Myeloid Leukemia, No.=Number of, SD=Standard Deviation.