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. 2013 Oct 7;10:103. doi: 10.1186/1742-4690-10-103

Table 2.

Studies of passive immunization in newborn macaques

Treatment
 Challenge
 Sterile protection References
Antibody (Route, Concentration) Infusion timing Virus Route
SIV hyperimmune serum (SC, 20 mL/kg)
 - Postnatal 2 days before challenge
 SIVmac 251 (105 TCID50)
 Oral
 - 2/2
 [1]
- Postnatal 2 days before challenge and 5 and 12 days after challenge
 - 4/4
- Postanatal 3 weeks after challenge
 - 0/3
- HIV immune globin (HIVIG) (IV, 400 mg/kg)
 Postnatal 24 hours before challenge
 SHIV89.6PD (40 TCID50)
 IV
 - 0/3
 [3]
- 2F5 (IV, 15 mg/kg)
 - 0/3
- 2G12 (IV, 15 mg/kg)
 - 0/3
- 2F5 / 2G12 (IV, 15 mg/kg of each)
 - 0/3
- HIVIG/2F5/2G12 (IV, 400 mg/kg of HIVIG, 15 mg/kg of each HuMoNAb)
 - 3/6
F105/2G12/2F5 (IV, 10 mg/kg of each)
 Pre- and postnatal 1–4 hours before and 8 days after challenge
 SHIVIIIB-vpu+ (10 AID50)
 Oral
 4/4
 [4]
2G12/b12/2 F5 (IV, 10 mg/kg of each)
 Postnatal 1 hour before and 8 days after challenge
 - SHIVIIIB-vpu+ (10 AID50)
 Oral
 - 2/2
 [148]
- SHIV-89.6P (15 AID50)
 - 1/4
F105/2G12/2F5 (IV, 10 mg/kg of each)
 - Postnatal 3–4 hours before challenge and 8 days after challenge
 SHIVIIIB-vpu+ (10 AID50)
 Oral
 - 2/2
 [149]
- Postnatal 1 hour and 8 days after challenge
 - 2/2
2G12/b12/2F5/4E10 (IV, 30 mg/kg of each except 4E10 at 11.5 mg/kg)
 Postnatal 1 hour and 8 days after challenge
 SHIV-89.6P (15 AID50)
 Oral
 2/4
 [6]
2G12/2F5/4E10 (IM, 40 mg/kg of each)
 Postnatal 1 hour and 8 days after challenge
 SHIV-89.6P (15 AID50)
 Oral
 4/4
 [150]
- 2G12/b12/2 F5/4E10 (IV, 30 mg/kg of each)
 - Postnatal 1 hour and 8 days after challenge
 SHIV-89.6P (15 AID50) Oral - 3/4
 [151]
- Post natal 12 hours and 8 days after challenge
 - 1/4
- 2G12/2F5/4E10 (IM, 40 mg/kg of each) - Postnatal 24 hours and 9 days post challenge - 0/4

TCID50: 50% tissue culture infectious dose; AID50: 50% animal infectious dose.

SC: subcutaneous; IV: intravenous; IM: intramuscular.