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The effects of protein kinase C-β (PKC-β) activity inhibition on tight junction protein levels and cytoskeleton. Occludin (A) and zonula occludens-1 (B) expressions and actin cytoskeleton staining (C) in human brain microvascular endothelial cells. Data are expressed as mean±s.e.m. from four different experiments. *P<0.05 versus normoglycemia (NG), †P<0.05 versus hyperglycemia (HG). siRNA, small interfering RNA.
