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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Cancer Res. 2013 Aug 23;73(23):10.1158/0008-5472.CAN-13-1550. doi: 10.1158/0008-5472.CAN-13-1550

Figure 6. Synergistic effect of PD-1 blockade, GVAX vaccination, and α4-1BB costimulation on immune activation.

Figure 6

TILs from regressing tumors of ID8 mice were harvested a week following completion of treatment and stained for various markers. Percentages of CD8+ and CD4+ TIL (CD45+) infiltration of total leucocytes are shown in treated versus untreated groups. The ratio of CD8+ T cells to Tregs and MDSC are also shown. Percentages of Ki67+CD8+ and MFI of Granzyme B+CD8+ TIL (CD45+) infiltration of total leukocytes are shown in treated versus untreated groups. Mean intensity of pT-bet, pEomes, and pS6 expression by CD8+ TILs is shown. Results from one of the 3 experiments are shown. Bars represent mean ± SEM. *P ≤ 0.05; **P ≤ 0.01; ***P < 0.001.