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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Blood Cells Mol Dis. 2013 Jul 24;52(1):10.1016/j.bcmd.2013.06.005. doi: 10.1016/j.bcmd.2013.06.005

FIG. 3. Hematopoietic failure and abnormal apoptotic signaling in FA.

FIG. 3

Mutations in any of FA genes lead to enhanced apoptotic signaling therefore cause excessive HSPC apoptosis. Compensatory chronic proliferation along with the FA genomic instability provoke leukemogenesis and results in typical phenotype such as developmental abnormalities, bone marrow failure, and cancer in FA patients. BMF = bone marrow failure