Table 3.

Summary of case reports with pituitary and adrenal involvement in patients with lymphoma

Age/gender	Pathology	Presenting symptoms	Involved sites	Lymphoma treatment	Hormonal treatment	Prognosis, survival	Reference
77/M	NHL diffuse large cell	Hyponatremia, Hypoglycemia, Weakness, Confusion	Pituitary gland, Bilateral adrenal glands	No treatment	T4, GC	Died, 9 weeks	[5]
59/M	DLBCL	Weakness, Ptosis, Mild Hyponatremia, Headache	Pituitary gland, Bilateral adrenal glands	R-CHOP, IT MTX	T4, GC, T, Fludro	Alive, 18 months	[6]
77/M	DLBCL	Fever, Hyponatremia, Ptosis	Pituitary gland, Bilateral adrenal glands, Liver, Spleen, Bone marrow	CHOP, IT MTX	GC	Died, 12 months in remission	[1]
63/M	DLBCL	Polyuria, Polydipsia, Miosis, Ptosis, Hypohidrosis of his left side	Pituitary gland, Bilateral adrenal glands, Lung	R-CHOP, HD-MTX, IT MTX, auto-HSCT	T4, GC, Desmo	Alive, 15 months	This report

M male, NHL non-Hodgkin’s lymphoma, DLBCL diffuse large B-cell lymphoma, CHOP cyclophosphamide, doxorubicin, vincristine, prednisolone, IT intrathecal injection, MTX methotrexate, R-CHOP rituximab combined with CHOP.

HD high dose, auto-HSCT autologous hematopoietic stem cell transplantation, T4 thyroxin, GC glucocorticoid, T testosterone, Desmo desmopressin, Fludro fludrocortisone.