Table 1.
NPC patients’ characteristics and clinical-pathologic features for the whole cohort and different racial groups.
| Total (n=5,868) |
Non- Hispanic white (n=2,901) |
Hispanic white (n=212) |
Black (n=527) |
Asian (n=1,945) |
Other (n=232) |
P | |
|---|---|---|---|---|---|---|---|
| Gender | 0.081 | ||||||
| Male | 3983 (68.5) | 1954 (67.4) | 141 (66.5) | 374 (71.0) | 1340 (68.9) | 174 (75.0) | |
| Female | 1834 (31.5) | 947 (32.6) | 71 (33.5) | 153 (29.0) | 605 (31.1) | 58 (25.0) | |
| Age at diagnosis | 54.7±16.6 | 58.1±16.9 | 52.2±19.2 | 48.3±18.2 | 51.9±14.5 | 51.1±14.6 | <0.001 |
| Histologic type | <0.001 | ||||||
| Keratinizing squamous cell carcinoma | 2456 (42.2) | 1520 (52.4) | 89 (42.0) | 226 (42.9) | 549 (28.2) | 72 (31.0) | |
| Differentiated non-keratinizing carcinoma | 664 (11.4) | 208 (7.2) | 24 (11.3) | 54 (10.2) | 333 (17.1) | 45 (19.4) | |
| Undifferentiated non-keratinizing carcinoma | 1172 (20.1) | 412 (14.2) | 33 (15.6) | 106 (20.1) | 552 (28.4) | 69 (29.7) | |
| Others | 1525 (26.2) | 761 (26.2) | 66 (31.1) | 141 (26.8) | 511 (26.3) | 46 (19.8) | |
| In situ/Malignant tumors in lifetime | <0.001 | ||||||
| One primary only in lifetime | 4793 (82.4) | 2255 (77.7) | 179 (84.4) | 428 (81.2) | 1729 (88.9) | 202 (87.1) | |
| First of two or more primaries | 537 (9.2) | 304 (10.5) | 14 (6.6) | 50 (9.5) | 152 (7.8) | 17 (7.3) | |
| Second of two or more primaries | 409 (7.0) | 285 (9.8) | 13 (6.1) | 41 (7.8) | 58 (3.0) | 12 (5.2) | |
| Third of three or more primaries | 66 (1.1) | 49 (1.7) | 6 (2.8) | 6 (1.1) | 4 (0.2) | 1 (0.4) | |
| Forth of four or more primaries | 12 (0.2) | 8 (0.3) | 0 (0) | 2 (0.4) | 2 (0.1) | 0 (0) | |
| Stage | <0.001 | ||||||
| In situ | 9 (0.2) | 7 (0.3) | 0 (0) | 2 (0.5) | 0 (0) | 0 (0) | |
| Localized | 671 (15.9) | 389 (18.3) | 26 (17.7) | 47 (12.3) | 195 (13.9) | 14 (8.3) | |
| Regional | 2764 (65.4) | 1294 (60.9) | 101 (68.7) | 243 (63.8) | 1013 (72.2) | 113 (66.9) | |
| Distant | 782 (18.5) | 435 (20.5) | 20 (13.6) | 89 (23.4) | 196 (14.0) | 42 (24.9) | |
| Grade | <0.001 | ||||||
| Grade • • | 154 (3.8) | 126 (6.4) | 4 (2.7) | 7 (2.1) | 16 (1.2) | 1 (0.6) | |
| Grade • • | 563 (14.0) | 394 (20.1) | 25 (16.8) | 57 (16.7) | 75 (5.4) | 12 (6.8) | |
| Grade • • | 2104 (52.4) | 1045 (53.3) | 73 (49.0) | 168 (49.3) | 730 (52.5) | 88 (50.0) | |
| Grade • • | 1196 (29.8) | 396 (20.2) | 47 (31.5) | 109 (32.0) | 569 (40.9) | 75 (42.6) | |
| Tumor size (mm) | 38.1±41.5 | 39.9±55.1 | 40.0±20.5 | 42.0±22.0 | 35.1±29.5 | 38.0±22.6 | 0.205 |
| Regional nodes positive | <0.001 | ||||||
| All nodes negative | 1826 (34.0) | 1045 (40.0) | 57 (30.2) | 157 (31.6) | 516 (27.8) | 51 (23.2) | |
| One or more nodes positive | 3549 (66.0) | 1566 (60.0) | 132 (69.8) | 340 (68.4) | 1342 (72.2) | 169 (76.8) | |
| Treatment | <0.001 | ||||||
| No treatment | 323 (5.8) | 178 (6.5) | 11 (5.4) | 41 (8.2) | 77 (4.1) | 16 (7.1) | |
| Surgery | 293 (5.3) | 211 (7.8) | 15 (7.4) | 31 (6.2) | 30 (1.6) | 6 (2.7) | |
| Radiation | 3883 (70.0) | 1726 (63.4) | 128 (63.4) | 314 (63.1) | 1542 (81.1) | 173 (76.5) | |
| Radiation & Surgery | 1050 (18.9) | 607 (22.3) | 48 (23.8) | 112 (22.5) | 252 (13.3) | 31 (13.7) | |
| Survival time (month) | 124.2±2.4 | 100.4±2.9 | 122.3±12.1 | 111.6±7.0 | 163.9±4.7 | 117.4±11.1 | <0.001 |
Cancers diagnosed 1973–2009 in the SEER 9 database. For a continuous variable, mean ± standard deviation, and for a categorical variable, count (percentage).