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Targeting AKT/mTOR had a therapeutic significance on ALK + tumor cells. (A) Synergistic growth inhibition between the dual PI3K/mTOR inhibitor, NVP-BEZ235, and Dex in all cells, especially in BaF3/NPM-ALK. (B) A higher apoptosis rate in cells treated with NVP-BEZ235 and Dex together compared with single use of the drugs.
