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The parameter ranges explored by previous work on compensatory evolution. θ = 4Nµ where N is the diploid population size, µ is the per-locus mutation rate and s is the selection coefficient against deleterious intermediates. All of these studies also explored recombination. In black: Kimura [13]. In grey: Iizuka and Takefu [14]. In transparent red box: Stephan [17]. In pink: Michalakis and Slatkin [15]. In purple: Higgs [18]. In light blue: Innan and Stephan [19].
