Table 2.
Cytotoxicity of the studied extracts towards sensitive and drug-resistant cancer cell lines and normal cells as determined by the resazurin assay
|
Cell lines |
Samples, IC50values (μg/mL) and degree of resistancea(in brakets) |
||||||
|---|---|---|---|---|---|---|---|
| Crinum zeylanicum | Dioscorea bulbifera | Elaoephorbia drupifera | Entada abyssinica | Eremomastax speciosa | Polistigma thonningii | Doxorubucin | |
| CCRF-CEM |
17.22 ± 2.19 |
19.77 ± 2.22 |
11.86 ± 1.19 |
15.81 ± 1.47 |
23.65 ± 2.51 |
26.44 ± 1.18 |
0.11 ± 0.01 |
| CEM/ADR5000 |
23.67 ± 1.97 (1.38) |
- (>2.02) |
13.72 ± 0.97(1.12) |
- (>2.53) |
38.71 ± 4.12 (1.64) |
- (>1.51) |
195.12 ± 14.30 (1772) |
| MDA-MB231 |
18.01 ± 1.61 |
33.17 ± 2.91 |
8.40 ± 0.55 |
29.14 ± 1.83 |
35.13 ± 2.49 |
34.19 ± 2.24 |
1.10 ± 0.01 |
| MDA-MB231/BCRP |
11.18 ± 1.11 (0.62) |
- (>1.21) |
30.96 ± 2.74(3.69) |
- (>1.37) |
- (>1.14) |
- (>1.17) |
7.83 ± 0.01 (7.11) |
| HCT116 (p53+/+) |
4.32 ± 0.52 |
36.14 ± 2.37 |
25.36 ± 2.13 |
9.55 ± 1.11 |
- |
- |
1.43 ± 0.02 |
| HCT116 (p53-/-) |
7.45 ± 0.64 (1.73) |
- (<0.69) |
28.61 ± 3.08(1.13) |
14.38 ± 1.25 (1.51) |
- |
- |
4.06 ± 0.04 (2.84) |
| U87MG |
- |
- |
23.58 ± 2.20 |
- |
- |
34.22 ± 2.74 |
1.06 ± 0.03 |
| U87MG.ΔEGFR |
- |
27.76 ± 1.86(<0.69) |
16.03 ± 0.88(0.68) |
- |
- |
- (>1.17) |
6.11 ± 0.04 (5.76) |
| Hep-G2 |
- |
- |
23.23 ± 1.67 (1.72) |
- |
- |
- |
1.41 ± 0.12 (<0.04) |
| AML12 | - | - | - | - | - | - | - |
aThe degree of resistance (in brakets) was determined as the ratio of IC50 value of the resistant/IC50 sensitive cell line; (-): >40 μg/mL.