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Multiple oral administrations of 17-DMAG induced a similar radioprotective efficacy to a single administration. (A) 17-DMAG (10 mg/kg) or vehicle was given twice (2×) at −48 and −24 h, (B) given three times (3×) at −72, −48, and −24 h, or (C) given five times (5×) at −120, −96, −72, −48, and −24 h prior to irradiation at 8.75 Gy (N = 16 mice per group). Veh: vehicle; 17-D: 17-DMAG; RI: radiation injury.
