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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Am J Reprod Immunol. 2013 Dec;70(6):10.1111/aji.12171. doi: 10.1111/aji.12171

FIG. 3. IL-23 induces production of IL-17 and IL-22 but not TNFα or IFNγ in the genital tract during C. muridarum infection.

FIG. 3

(A–D) Levels of IL-17 (A) and IL-22 (B) in the vaginal lavages of IL-23p19 KO mice (clear circles, dashed line) were significantly reduced over the course of infection compared to C57BL/6 mice (black squares), but no difference was detected for TNFα (C) or IFNγ (D). Data points represent the mean ± SEM for 4–5 mice per strain from one representative experiment of two. @, P < 0.05 for IL-17 and IL-22 (by two-way ANOVA over the interval measured). *, P < 0.05; ***, P < 0.001 on individual days (by two-way ANOVA with Bonferroni post-test analysis). (E–H) Measurement of cytokines in the homogenized oviducts of infected mice revealed significantly reduced levels of IL-17 (E) and IL-22 (F) over the course of infection in the absence of IL-23 but no difference in TNFα (G) and IFNγ (H). Data points represent the mean ± SEM for 3–5 mice strain per day. @, P < 0.05 for IL-17 and IL-22 (by two-way ANOVA over the interval measured). ***, P < 0.001 for IL-22 on individual days by (two-way ANOVA with Bonferroni post-test analysis).