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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: J Neuroimmunol. 2013 Sep 20;265(0):10.1016/j.jneuroim.2013.09.013. doi: 10.1016/j.jneuroim.2013.09.013

Fig. 1.

Fig. 1

Chronic morphine exposure increases the level of circulating Treg cells. Rhesus macaque PBMCs were stained for cell surface expression of CD3 (PacBlue), CD4 (Qdot605), and CD25 (APC-Cy7) followed by intracellular staining for FoxP3 (APC). Representative data for the co-expression of CD25 and FoxP3 (a, b) on CD3+CD4+ cells for animals at 0 week (a) and 12 weeks (b) of morphine administration are presented. The combined results for all of the macaque animals (5 animals) are presented as the percent of CD3+CD4+ which are CD25+FoxP3+ dual-positive cells (c). Data are presented as the mean (± sem) for the 5 animals. **p<0.01.