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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Future Microbiol. 2013 Jun;8(6):10.2217/fmb.13.39. doi: 10.2217/fmb.13.39

Figure 3. A selection of the reported medicinal chemistry modifications that have been made to the polymyxin core structural domains.

Figure 3

The hydrophobic N-terminal fatty acyl chain (red), the linear tripeptide segment (green), the hydrophobic motif at positions 6 and 7 (blue) and the heptapeptide backbone (pink) are shown. Modifications to the diaminobutyric acid residue positions are not depicted.