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Keap1 reacts in a Michael addition with a polyphenol oxidized to the corresponding orthoquinone (or paraquinone) form . The alkylation of Keap1 permits Nrf2 to escape ubiquitinylation and degradation. As described in the text, phosphorylation is also required for Nrf2 translocation to the nucleus and activation of transcription through EpRE.
