Table 4.

Five example homologous E. coli and Brucella genes and their associated genes

Gene Name	Associated E coli genes	Associated Brucella genes
dnaK	abgT*, alaS, argP, clpB, clpP, cspA, dnaJ, ftsH, grpE, groS, pflA, rcsAm uspA, ybcY, ydfE, ... (total: 21)	clpP, dnaJ, groEL, groES, omp25, sodC, virB10, virB11, sucB, chvL, rplL, rRNA
fliF	carB, cspA, cysH, fliC, fliE, ligT, lysR, phoQ, ompA, phoB, rpoD, rpoN, tonB, yfbY, zapA, ... (total: 176)	flgE, fliC, rpoD, rpoN
Hfq	bacA, csrB, deaD, deoD, dsrA, gadY, gcvB, katE, micA, oxyS, recA, rprA, rprA, rpoS, sgrS, sodC, stpA, ... (total: 118)	bacA, chvG, chvI, katA, sodC, virB1, virB2, virB5
purE	argD, aroE, cpdB, lysA, metE, metF, ompA, purK, pyrC, rpsE, relA, rpoB, serB, ... (total: 519)	chvl, omp25, omp28, sodC, virB1, virB2, wboA, znuA
rpoB	betA, dnaK, era, fliF, folD, fur, gyrA, gyrB, map, minD, polA, purE, recA, rho, secD, ... (total: 335)	groEL, gyrA, gyrB, katA, omp2b, parC, recA, rRNA

*Note: To be included as an associated gene with one of the five selective target genes, the gene needs to share at least one co-publication with the target gene, or the two gene pair has a p-value < 0.05 based on the GenoMesh dissimilarity calculation.