. 2013 Oct 11;13:261. doi: 10.1186/1472-6882-13-261

Table 3.

IC₅₀values obtained by using different cytotoxicity assays- MTT, NRU and LDH release

Mushroom/Plant	Species	Extracts	Neuroblastoma 2a cells			3T3 embryonic fibroblast
			IC₅₀(mg/ml) after 24 h			IC₅₀(mg/ml) after 24 h
			MTT	NRU	LDH	MTT	NRU	LDH
Culinary/medicinal mushroom	Pleurotus giganteus	Aqueous	4.07 ± 0.67^e	6.95 ± 1.00^g	-	2.16 ± 0.05^c	2.67 ± 0.47^d	-
	Pleurotus pulmonarius		2.85 ± 0.06^cd	2.13 ± 0.87^cdef	-	1.75 ± 0.14^bc	2.60 ± 0.55^d	-
	Lignosus rhinocerotis (sclerotium)		3.27 ± 0.77^d	2.72 ± 0.65^ef	-	5.63 ± 0.06^e	5.93 ± 0.05^f	-
	Lignosus rhinocerotis		2.43 ± 0.12^c	1.75 ± 0.18^abc	-	5.23 ± 0.17^e	5.60 ± 0.1^f	-
	(mycelium)		2.43 ± 0.12^c	1.75 ± 0.18^abc	-	5.23 ± 0.17^e	5.60 ± 0.1^f	-
	Hericium erinaceus		2.60 ± 0.52^cd	2.85 ± 0.56^e	-	3.43 ± 0.29^d	3.53 ± 0.06^e	-
	Ganoderma lucidum		1.35 ± 0.03^a	1.52 ± 0.17^ab	2.20 ± 0.52^ab	1.19 ± 0.06^ab	1.35 ± 0.02^ab	1.50 ± 0.08^a
	Ganoderma neo-japonicum		1.17 ± 0.006^a	1.11 ± 0.03^a	2.00 ± 0.53^ab	1.47 ± 0.37^ab	1.78 ± 0.56^bc	1.58 ± 0.44^a
	Grifola frondosa		2.72 ± 0.08^cd	4.60 ± 1.10^f	-	6.67 ± 0.87^f	7.60 ± 0.1^g	-
	Pleurotus giganteus	Ethanol	2.43 ± 0.10^c	2.81 ± 0.15^e	5.8 ± 0.10^c	1.66 ± 0.56^bc	1.96 ± 0.42^c	1.73 ± 0.48^a
	Pleurotus pulmonarius		2.30 ± 0.72^bc	2.64 ± 0.16^def	2.53 ± 0.96^bc	1.27 ± 0.06^ab	1.48 ± 0.05^abc	1.67 ± 0.12^a
	Hericium erinaceus		2.47 ± 0.50^c	1.61 ± 0.51^ab	2.10 ± 0.72^ab	1.31 ± 0.03^ab	1.84 ± 0.57^bc	1.47 ± 0.31^a
	Cordyceps militaris		1.65 ± 0.015^ab	1.81 ± 0.10^abcd	2.37 ± 0.21^b	1.02 ± 0.08^a	1.10 ± 0.02^a	1.40 ± 0.29^a
Medicinal plant	Lycium barbarum	Aqueous	4.37 ± 1.00^e	6.96 ± 0.73^g	-	8.40 ± 0.72^g	7.86 ± 0.06^g	-
	Gingko biloba	Ethanol	1.56 ± 0.08^ab	1.66 ± 0.11^ab	1.43 ± 0.39^a	1.56 ± 0.58^abc	1.37 ± 0.07^ab	1.78 ± 0.07^a
	Curcumin	Compound	1.13 ± 0.01^a	1.15 ± 0.01^a	1.30 ± 0.16^a	1.16 ± 0.06^ab	1.23 ± 0.03^ab	1.60 ± 0.22^a

The data represent the mean ± SD of three determinations. Means not sharing a common letter were significantly different at p < 0.05.