Table 2.
Clinical variables, summary of dosimetric statistics and correlation coefficient (Rs) with radiation-induced late gastro-intestinal toxicity incidence
| |
|
Univariate analysis |
||
|---|---|---|---|---|
| Characteristic | Rs | p-value | ||
|
Categorical |
N |
% |
|
|
| Age (y) |
|
|
|
|
| ≤70 |
19 |
33.3 |
|
|
| >70 |
38 |
66.7 |
0.105 |
.436 |
| Tumor size |
|
|
|
|
| <T3 |
48 |
84.2 |
|
|
| ≥T3 |
9 |
15.8 |
-0.044 |
.752 |
| PSA |
|
|
|
|
| ≤15 |
35 |
61.4 |
|
|
| >15 |
22 |
38.6 |
0.051 |
.707 |
| Gleason score |
|
|
|
|
| ≤6 |
34 |
59.7 |
|
|
| >6 |
23 |
40.3 |
0.143 |
.315 |
| Hormonal therapy |
|
|
|
|
| Yes |
53 |
7.0 |
|
|
| No |
4 |
93.0 |
-0.097 |
.472 |
| Previous abdominal surgery |
|
|
|
|
| Yes |
26 |
45.6 |
|
|
| No |
31 |
54.4 |
0.025 |
.854 |
| Diabetes |
|
|
|
|
| Yes |
14 |
24.6 |
|
|
| No |
43 |
75.4 |
-0.058 |
.670 |
| Smokers |
|
|
|
|
| Yes |
31 |
54.4 |
|
|
| No |
26 |
45.6 |
0.199 |
.137 |
| Antihypertensive/anticoagulants |
|
|
|
|
| Yes |
37 |
64.9 |
|
|
| No |
20 |
35.1 |
-0.338 |
.010 |
| Acute GI toxicity |
|
|
|
|
| Yes |
21 |
36.8 |
|
|
| No |
36 |
63.2 |
0.309 |
.020 |
| Radiation treatment |
|
|
|
|
| CRT |
26 |
45.6 |
|
|
| ART |
31 |
54.4 |
-0.174 |
.195 |
|
Continuous |
Median (range) |
|
|
|
| Dmax (Gy) |
76.2 (47.2-79.7) |
|
-0.009 |
.947 |
| Dmean (Gy) |
43.2 (14.9-74.9) |
|
0.242 |
.035 |
| V30 (%) |
67.1 (16.8-100) |
|
0.203 |
.131 |
| V40 (%) |
49.4 (12.3-100) |
|
0.244 |
.067 |
| V50 (%) |
39.8 (8.2-99.1) |
|
0.274 |
.039 |
| V60 (%) |
30.1 (2.6-98.0) |
|
0.282 |
.034 |
| V65 (%) |
27.0 (0.4-98.2) |
|
0.284 |
.032 |
| V70 (%) |
26.8 (0.0-97.0) |
|
0.255 |
.056 |
| V75 (%) | 7.6 (0.0-81.7) | 0.068 | .615 | |