Table 1.
Comparison of clinical factors and outcome variables in patients with recurrent glioblastoma treated with different approaches
| |
Salvage treatment |
||||
|---|---|---|---|---|---|
| Characteristics |
Re-irradiation |
Re-surgery |
Chemotherapy |
Best supportive care |
p Value |
| (N= 15) | (N=6 ) | (N=37 ) | (N=25 ) | ||
| Age (years) |
|
|
|
|
|
| Median |
51.5 |
65 |
66 |
66 |
RT vs no-RT 0.002 |
| Range |
41-73 |
55-73 |
49-72 |
55-79 |
|
| <60 years |
5 |
3 |
21 |
20 |
|
| <=60 years |
10 |
3 |
16 |
5 |
0.02 |
| Gender, N0. (%) |
|
|
|
|
|
| Men |
11 (73%) |
4 (67%) |
22 (59%) |
9 (38%) |
0.33 |
| Women |
4 (27%) |
2 (33%) |
15 (41%) |
16 (62%) |
|
| Primary Surgery, N0. (%) |
|
|
|
|
|
| Total |
11 (73%) |
4 (67%) |
18 (49%) |
10 (39%) |
0.18 |
| Subtotal |
3 (20%) |
2 (33%) |
11 (30%) |
4 (15%) |
|
| Biopsy |
1 (7%) |
0 |
8 (21%) |
11 (46%) |
|
| Karnofsky performance status at diagnosis (%) |
|
|
|
|
. |
| Median |
90 |
90 |
90 |
90 |
n.s |
| Range |
80-100 |
80-100 |
70-100 |
70-100 |
|
| RPA classification at diagnosis, N0. (%) |
|
|
|
|
|
| IV |
9 (60%) |
5 (83%) |
18 (50%) |
13 (54%) |
|
| V |
5 (33%) |
1 (17%) |
8 (20%) |
6 (23%) |
|
| VI |
1 (7%) |
0 |
11 (30%) |
6 (23%) |
|
| MGMT Methylation, N0. (%) |
|
|
|
|
|
| Yes |
7 (47%) |
4 (67%) |
12 (33%) |
10 (38%) |
0.47 |
| No |
5 (33%) |
2 (33%) |
20 (54%) |
13 (54%) |
|
| Unknown |
3 (20%) |
0 |
5 (13%) |
2 (8%) |
|
| Primary Tumor location, N0 (%) |
|
|
|
|
|
| Frontal |
3 (20%) |
3 (50%) |
12 (34%) |
10 (39%) |
0.72 |
| Temporal |
4 (27%) |
3 (50%) |
13 (35%) |
6 (23%) |
|
| Parietal |
6 (40%) |
0 |
8 (21%) |
6 (23%) |
|
| Occipital |
2 (13%) |
0 |
4 (10%) |
3 (15%) |
|
| Primary Tumor side, N0 (%) |
|
|
|
|
|
| Left |
8 (53%) |
4 (67%) |
20 (54%) |
14 (54%) |
0.96 |
| Right |
7 (47%) |
2 (33%) |
17 (46%) |
11 (46%) |
|
| Type of recurrence, N0 (%) |
|
|
|
|
|
| In-field |
9 (60%) |
5 (83%) |
32 (86%) |
19 (77%) |
|
| Out-field |
6 (40%) |
1 (17%) |
5 (14%) |
6 (23%) |
0.19 |
| Karnofsky performance status at recurrence (%) |
|
|
|
|
|
| Median |
90 |
90 |
80 |
80 |
n.s. |
| Range |
80-100 |
80-100 |
70-100 |
70-100 |
|
| Median OS from primary diagnosis (months) |
33 |
17 |
17 |
9.9 |
RT vs no-RT 0.001 |
|
Cox regression analysis OR coef f-p |
0.102 |
0.268 |
0.331 |
1 |
|
| 1.4e-07 |
0.016 |
0.00018 |
- |
|
|
| Time between primary therapy and salvage treatment |
|
|
|
|
|
| Median (months) |
10.8 |
10 |
8 |
5 |
0.003 |
| Range (months) |
6-54 |
7-24 |
7-21 |
2-11 |
|
| Median OS from recurrence(months) |
9.5 |
5.5 |
5.5 |
2.5 |
RT vs no-RT 0.001 |
| Cox regression analysisOR coef f-p | 0.16 |
0.34 |
0.33 |
1 |
|
| 0.000016 | 0.052 | 0.0015 | - | ||