Table 1.
Demographic Features, Ovarian Reserve Hormonal Profile, and Antral Follicle Count in SLE Patients and Controls
| SLE-CTX group (n=19) | SLE group (n=23) | Control group (n=21) | P | |
|---|---|---|---|---|
| Mean age (years) | 28.87±5.27 | 30.00±4.37 | 28.95±6.03 | 0.747 |
| Mean age at menarche (years) | 13.90±1.52 | 13.20±1.47 | 13.46±0.83 | 0.392 |
| Body mass index (kg/m2) | 21.60±1.20 | 20.30±2.29 | 20.54±1.86 | 0.114 |
| Mean duration of disease (years) | 2.27±1.69 (0.5–6) | 3.04±2.79 (0.5–12) | – | 0.299 |
| Mean SLEDAI | 5.10±3.59 (0–15) | 2.09±1.81 (0–6) | – | 0.039 |
| Median dosage of CTX (g) | 4.05 (0.70–20.90) | – | – | – |
| Median dosage of prednisone (mg/d) | 20 (0–40) | 10 (0–20) | – | – |
| Mean dosage of prednisone (mg/d) | 16.26±12.84 | 8.70±6.94 | – | 0.020 |
| FSH (IU/L) | 7.34±5.34 | 5.18±1.52 | 4.85±1.00 | 0.207 |
| LH (IU/L) | 3.51±1.71 | 3.79±2.08 | 3.14±1.47 | 0.518 |
| E2 (pg/mL) | 53.27±30.01a | 44.20±14.22a | 36.10±10.48b | 0.007 |
| AMH (ng/mL) | 1.15±1.28a | 1.71±1.29a | 3.33±1.76b | 0.000 |
| AFC | 7.80±4.54a | 10.90±3.00a | 14.61±4.93b | 0.001 |
Values expressed in mean±SD or median (range). a vs. b, P<0.05.
AMH, anti-Müllerian hormone; AFC, antral follicle count; CTX cyclophosphamide; E2, estradiol; FSH, follicle stimulating hormone; LH, luteinizing hormone; SLE, systemic lupus erythematosus; SLEDAI, SLE disease activity index.