FIG. 1.

Effects of HCD and/or LPS challenge on liver steatosis, damage and iNOS levels in WT mice. (A) Representative photomicrographs of the H&E staining (20×) of liver sections. (B) Lipids were quantified from whole livers of high-cholesterol or control-diet fed mice injected with LPS or PBS (control). (C) Plasma ALT (D) AST (E) and liver iNOS protein and (F) mRNA levels after chronic HCD and/or LPS challenge. Values are expressed as mean±SEM (n=8–9 for each group). Means without a common letter are statistically different. Con, control; Chol, cholesterol; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HCD, high-cholesterol diet; iNOS, inducible nitric oxide synthase; WT, wild-type; LPS, lipopolysaccharide; PBS, phosphate-buffered saline; H&E, hematoxylin & eosin. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars