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. 2013 Dec 1;19(16):1889–1901. doi: 10.1089/ars.2012.5157

FIG. 8.

FIG. 8.

Effect of HCD and/or endotoxemia on cytoprotective properties of iNOS and plasma cytokine levels. (A,B) HO-1, (C,D) IL-6 and (E,F) TNFα mRNA levels in WT mice after chronic HCD and/or LPS challenge or in WT and iNOS-deficient mice subjected to HCD and LPS challenge. (G) Plasma concentrations of IL-6 and (H) TNFα in WT and iNOS-deficient mice subjected to HCD and LPS challenge. (I) Lipid peroxidation levels evaluated in WT and iNOS-deficient mice subjected to HCD and LPS challenge. Values are expressed as mean±SEM (n=6-9 for each group for mRNA expression and lipid peroxidation or n=3 for cytokines plasma concentrations). Means without a common letter are statistically different. *p<0.05 versus WT group. HO-1, heme oxygenase-1; TNFα, tumor necrosis factor-α.