Table 1. Directional expression divergence between Malaysian and wine/European yeast in coregulated gene groups.

Group	Annotation	Upregulated	Adjusted P
Node 7	Ribosomal proteins	Malaysian	<0.0001
AFT1 targets	Iron homeostasis	Wine/European	0.0078
Node 36	Enzymes	Malaysian	0.0156
GO:0007039	Vacuolar protein catabolic process	Malaysian	<0.0001
GO:0006519	Cellular amino acid metabolic process	Wine/European	0.0100
GO:0006725	Cellular aromatic acid metabolic process	Wine/European	0.0133
GO:0006811	Ion transport	Wine/European	0.0300
GO:0006082	Organic acid metabolic process	Wine/European	0.0320
GO:0006826	Iron ion transport	Wine/European	0.0400
GO:0055085	Transmembrane transport	Wine/European	0.0400

Each row reports the results of a test for expression changes of the same sign between Malaysian and wine/European strains in one group of functionally related genes. Group indicates identifier of regulon (Gasch et al. 2004) or Gene Ontology term. Upregulated, population with elevated expression. Adjusted P indicates significance of a two-sided resampling test relative to the genomic null for an extreme value of the sum, across genes of the indicated regulon, of the signs of the log₂ ratio of expression in Malaysian yeast to wine/European yeast assessed using all isolates from each population and corrected for multiple testing with the Benjamini-Hochberg method. Shown is the set of tested groups significant at adjusted P < 0.05.