Figure 1.
Lens fiber cell differentiation is disrupted upon conditional inactivation of Dicer1. Analysis of lens development at E16.5 (A−F) and P2 (G−L). in control Dicer1flox/flox (A−C, G−I) and Dicer1flox/flox; MLR10-Cre mutant (D−F, J−L). The analysis presented includes hematoxylin and eosin staining (A, D, G, J), immunofluorescence staining for cleaved caspase 3 (B, E), E-cad (H, K), and γ-crystallins (C, F, I, L). Scale bar = 100 μm.