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Four sets of global GRNs. (A) “Early” up-miRNA:down-regulated mRNA. (B) “Late” up-miRNA:down-regulated mRNA. (C) “Early” down-miRNA:up-regulated mRNA. (D) “Late” down-miRNA:up-regulated mRNA. The diagrams were created using Cytoscape program as described in the Materials and Methods using only high-scoring and experimentally observed predictions. miRNA, triangles; mRNAs, circles; up-regulated (red); down-regulated (blue).
