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. 2013 Oct 18;3(12):2239–2255. doi: 10.1534/g3.113.008698

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Copyright © 2013 Wolf et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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An “early” connectivity network. Seven miRNAs, including miR-9, miR-137, miR-200c, miR-381, miR-455, miR-495, and miR-543, and connections to specific functional groups of genes are shown. (A) Connections to the group of three most-connected and regulated transcription factors (c-Maf, Nfib, and N-Myc). (B) Chromatin regulation (Ash1l, Med1/PBP, and 20 Kdm5b/Jarid1b/Plu1). (C) RNA metabolism (Cpsf6 and Tnrc6b). The miR-381, miR-495, miR-543, and miR-382 form a miRNA-gene cluster on rat chromosome 6q32. miRNA, triangles; mRNAs, circles; up-regulated (red); down-regulated (blue).