Table 2.
Parameters affected by covariates in the final model based on any decrease in AIC and subjective improvement in predicted-observed plots.
| Parameter | Covariates | ||||
|---|---|---|---|---|---|
| CYP3A5 | HCT | FFM | BMI | TXT | |
| Apparent clearance (CL/F) | X | X | X | ||
| Apparent intercompartment clearance (Q/F) | X | X | |||
| Apparent central volume of distribution (V/F) | X | X | |||
| Apparent peripheral volume of distribution (Vp/F) | X | X | |||
| Relative bioavailability (FA) | X | ||||
| Lag time first week (Tlag1) | X | Day 1–7 | |||
| Lag time week 2–4 (Tlag2) | X | Day 8–28 | |||
| Lag time after first month (Tlag3) | X | Day 29- | |||
CYP3A5, cytochrome P450-3A5; HCT, hematocrit; FFM, fat-free mass; BMI, body mass index; TXT, time after transplantation.